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. Author manuscript; available in PMC: 2013 Mar 23.
Published in final edited form as: Curr Mol Pharmacol. 2010 Jan;3(1):37–52. doi: 10.2174/1874467211003010037

Fig. 3. Signaling pathways that lead to STAT3 activation.

Fig. 3

a. STAT3 can be phosphorylated at Y705 directly by RTKs (EGFR and EGFRvIII) and non-receptor TK (JAK2) and becomes activated. Inactive JAK2 is constitutively bound to the G-protein coupled receptors (IL-R, LIF-R, gp130) and becomes auto-phosphorylated at Y1007/1008 upon receptor activation. In addition, JAK2 can be phosphorylated at Y1007/1008 directly by RTKs (EGFR/EGFRvIII and PDGFR) and non-receptor TK, Src.

b. STAT3 activation via S727 phosphorylation can be initiated by stimulation of EGF (via Akt, ERK, JNK and p38) and IL-6 (via PKCε).

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