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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Appetite. 2013 Jan 11;64:81–88. doi: 10.1016/j.appet.2012.12.023

Figure 1. Effects of chronic social stress and fluoxetine on meal patterning.

Figure 1

A. Eight-week-old male C57BL/6J mice were subjected to ten days of chronic social defeat stress (CSDS) and tested for social interaction. Animals displaying social avoidance along with nonstressed controls showing a social preference were randomized into two equal groups that received pellets releasing a 20-day supply of fluoxetine or placebo. A subset of mice from each experimental group (Supplemental Figure 1A) was pair-matched for body weight and monitored in metabolic cages 4 days after social interaction testing (days 33–36). Meal patterns were analyzed over 48 hours on days 34–36. B. Total chow consumed in the light phase (no effect) and dark phase (significant effect of defeat, F1,18 = 9.41). C. Meal number in the light phase (no effect) and dark phase (significant defeat X fluoxetine interaction, F1,18 = 9.11). D. Meal size in the light phase (no effect) and dark phase (significant defeat X fluoxetine interaction, F1,18 = 12.49). E. Satiety ratio calculated during the light phase (no effect) and dark phase (no effect). N = 5–6/group. *p< 0.05, **p < 0.01, ***p < 0.001. Data presented as mean ± S.E.M. D, Day.