Table 2.
Values for the three measures of biocompatibility for each microparticulate formulation
| Score | |||
|---|---|---|---|
| Scale | Day 4 | Day 14 | |
| Gross dissection | Lidocaine 10% | 1.0 (0.8–1.0) | -- |
| (0–3) | Bupivacaine 10% | 1.0 (1.0–1.3) | -- |
| P value* | 0.13 | ||
| Lidocaine 50% | 1.0 (1.0–1.3) | 1.0 (1.0–1.5) | |
| Bupivacaine 50% | 2.0 (1.8–2.0) | 2.0 (2.0–2.3) | |
| P value* | 0.12 | 0.11 | |
| Inflammation | Lidocaine 10% | 1.0 (1.0–1.2) | -- |
| (0–4) | Bupivacaine 10% | 1.4 (1.2–1.6) | -- |
| P value* | 0.27 | ||
| Lidocaine 50% | 3.0 (2.1–3.5) | 1.4 (1.3–1.6) | |
| Bupivacaine 50% | 2.7 (2.5–2.9) | 0.7 (0.5–1.1) | |
| P value* | 0.44 | 0.10 | |
| Myotoxicity | Lidocaine 10% | 1.2 (0.9–1.7) | -- |
| (0–6) | Bupivacaine 10% | 1.7 (1.5–1.9) | -- |
| P value* | 0.19 | ||
| Lidocaine 50% | 3.4 (2.1–4.2) | 1.9 (1.8–2.4) | |
| Bupivacaine 50% | 3.3 (2.9–3.5) | 1.7 (1.3–1.9) | |
| P value* | 0.44 | 0.23 | |
Values are medians with 25th and 75th percentiles in parentheses; n = 4 for all groups
Particles with 10% loading were tested at 4 days only
*
P value of Mann-Whitney U test comparing lidocaine to bupivacaine for equally loaded particles