Table 1.
Baseline physiologic data of piglets
| TIVA | ISO | |
|---|---|---|
| Weight (Kg) | 9.0 ± 1.0 | 8.2 ± 0.9 |
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| Rectal temperature (°C) | 36.7 ± 0.6 | 36.7 ± 0.5 |
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| Heart Rate | 111 ± 19 | 108 ± 17 |
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| Respiratory Rate | 26 ± 3 | 27± 2 |
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| SaO2 (%) | 98 ± 1 | 98 ± 1 |
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| MAP (mmHg) | 79 ± 10* | 55 ± 10 |
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| ICP (mmHg) | 8 ± 3 | 11 ± 3 |
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| CPP (mmHg) | 71 ± 11* | 45 ± 7 |
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| CBF (ml/100gm/min) | 35 ± 27 | 38± 10 |
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| PbtO2 (mmHg) | 10.8 ± 4.3 | 13.5 ± 4.7 |
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| pH | 7.53 ± 0.04 | 7.53 ± 0.02 |
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| pCO2 | 42.7 ± 3.1 | 40.0 ± 4.8 |
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| paO2 | 137.0 ± 25.2 | 132.8 ± 25.4 |
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| Lactate | 1.1 ± 0.3 | 1.6 ± 0.9 |
Values are mean ± standard deviation. Baseline measurements were performed in each animal before exposure to vasopressor drug. Total IV anesthesia (TIVA) = fentanyl and midazolam; ISO = fentanyl and isoflurane; SaO2 = arterial oxygen saturation; MAP = mean arterial blood pressure; ICP = intracranial pressure; CPP = cerebral perfusion pressure; CBF = cerebral blood flow; PbtO2 = brain tissue oxygen tension.
*
P< 0.001