Figure 8.

Significant signaling pathway networks mined from nitroproteomic dataset. (a) Network is derived from adenoma nitroproteomic data and function in cancer, cell cycle, reproductive system disease. A gray node denotes an identified nitroprotein or protein that interact with nitroproteins in our study. (b) Network is derived from control nitroproteomic data and function in gene expression, cellular development, and connective tissue development and function. A gray node denotes an identified nitroprotein in our studies. An orange solid edge denotes a direct relationship between two nodes (molecules: proteins, genes). An orange unsolid edge denotes an indirect relationship between two nodes (molecules: proteins, genes). The various shapes of nodes denote the different functions. A curved line means intracellular translocation; a curved arrow means extracellular translocation. Reproduced from Zhan and Desiderio [23], with permission from BioMed Central open access journal, copyright remains with the authors.