Table 2.
Effect ofSepsis/LPS on signaling to and from mTOR substrates and regulatory proteins
| Protein | Modification | Direction/Magnitude | Citation |
|---|---|---|---|
| Rat pAkt | T308, S473 | Decreased 50% | (14, 32, 50) |
| Mouse pAkt | S473 | No Change | (62) |
| pPRAS40 | T246 | Decreased 50% | (32, 50) |
| pmTOR | S2448/S2481 | Decreased 20–50% | (50, 54, 59) |
| pTSC2 | S939, T1462 | No Change | (32, 50) |
| TSC1/2 | Association | No Change | (32, 50) |
| pRaptor | pS792 | Increased 80% | (32, 50) |
| pAMPKα | T172 | Increased 50% | (50) |
| Raptor/mTOR | Association | No Change | (50) |
| Raptor/eIF3b | Association | Decreased 50% | (50, 64) |
| pS6K1 | T389 | Decreased Basal 70% | (32, 54) |
| pS6K1 | T389 | Decreased Leu stimulation 70% | (59, 60) |
| Raptor/S6K1 | Association | Increased 60% | (50) |
| pS6 | S240/S244 S235/S236 |
Decreased basal, Leu, and IGF-I stimulation 75% | (32, 60) |
| p4E-BP1 | T37/T46 | Decreased basal and Leu stimulation 80% | (33, 54, 59, 60) |
| 4E-BP1/4E | Association | Increased 50% | (54, 59, 60) |
| 4E-BP1/4E | Leu induced Disassociation | Blocked Completely | (59, 60) |
| Mouse 4E-BP1/Raptor | Association | Decreased 60% | (64) |
| Rat 4E-BP1/Raptor | Association | Increased 50% | (50) |
| Deptor | Total Protein/Mouse C2C12 | Decreased 30% | (33) |
| Deptor | Total Protein/Rat Muscle | Increased 60% | (50) |
Observations made in the above table summarize representative data specifically pertaining to skeletal muscleand in some cases C2C12 myotubes. A more in depth analysis may be found in the cited references.