Table 2.

Genomic single nucleotide polymorphisms most significantly associated (p ≤ 5.0 × 10⁻⁵) with motor outcome in Parkinson’s disease^a

Gene	SNP	Chromosome	Positionb	Location Relative to Gene	Allele	Minor Allele Frequency (%)	Log Additive Model HR (95% CI)	Log Additive Model P Valuec
C8orf4	rs10958605	8	40053605	3’ downstream	C>A	0.452	1.81 (1.42 – 2.31)	0.00000151
RPS17P6	rs10918653	1	167143896	5’ upstream	G>A	0.337	0.57 (0.44 – 0.74)	0.00000957
CACNB4	rs3768653	2	152716628	intronic SNP	C>A	0.184	1.90 (1.44 – 2.49)	0.0000121
ANK2	rs6819908	4	113887737	intronic SNP	C>G	0.232	1.76 (1.38 – 2.25)	0.0000133
ACTR3B	rs11773902	7	152501825	intronic SNP	A>G	0.377	1.75 (1.35 – 2.26)	0.000014
COL1A2	rs1861114	7	93883599	5’ upstream	T>G	0.076	0.36 (0.21 – 0.62)	0.000018
STARP1	rs1412907	13	65919459	5’ upstream	T>C	0.415	0.61 (0.48 – 0.77)	0.0000183
EPB41L3	rs1785423	18	5610882	5’ upstream	G>A	0.447	0.61 (0.49 – 0.77)	0.0000185
MAGI2	rs12534352	7	77643059	3’ downstream	A>G	0.251	1.66 (1.33 – 2.07)	0.0000201
STARP1	rs1333169	13	65907951	5’ upstream	G>A	0.116	2.07 (1.52 – 2.83)	0.0000207
STARP1	rs9317493	13	65832729	3’ downstream	A>G	0.416	0.62 (0.49 – 0.78)	0.0000334
SNX6	rs17524152	14	35067542	intronic SNP	T>A	0.434	0.63 (0.50 – 0.78)	0.0000347
STARP1	rs9571383	13	65939434	5’ upstream	G>T	0.443	1.62 (1.28 – 2.05)	0.0000415
PLCB4	rs4813881	20	8968642	5’ upstream	A>T	0.362	0.61 (0.48 – 0.78)	0.0000495

^aThe SNPs are listed in order of decreasing statistical significance as indicated by the uncorrected p values.

^bNCBI build 37.1 of the human genome.

^cuncorrected p values.

SNP = single nucleotide polymorphism; UTR = untranslated region; HR = hazard ratio; CI = confidence interval