Table 3.

Genomic single nucleotide polymorphisms significantly associated (p ≤ 5.0 × 10⁻⁵) with cognitive outcome in Parkinson’s disease^a

Gene	SNP	Chromosome	Positionb	Location Relative to Gene	Allele	Minor Allele Frequency (%)	Log Additive Model HR (95% CI)	Log Additive Model P valuec
CLRN3	rs6482992	10	129678674	intronic SNP	C>T	0.236	2.03 (1.47 – 2.79)	0.00000408
C4orf26	rs17000647	4	76481730	intronic SNP	C>A	0.025	5.58 (3.00 – 10.38)	0.00000483
LMNB1	rs959573	5	126181862	3’ downstream	C>T	0.258	0.52 (0.40 – 0.67)	0.00000527
C17orf68	rs3027247	17	8130867	intronic SNP	A>C	0.260	0.53 (0.40 – 0.71)	0.00000927
RNU7-2P	rs12621515	2	146780097	5’ upstream	C>A	0.109	2.26 (1.61 – 3.16)	0.0000123
RNU7-2P	rs16825922	2	146772505	5’ upstream	C>T	0.107	2.27 (1.62 – 3.18)	0.0000124
TRPM3	rs4143736	9	73517105	intronic SNP	G>A	0.250	0.51 (0.37 – 0.70)	0.0000124
RNU7-2P	rs16825883	2	146748264	5’ upstream	A>G	0.109	2.26 (1.61 – 3.17)	0.0000138
C8orf4	rs7014749	8	39943820	5’ upstream	A>G	0.025	6.08 (3.05 – 12.13)	0.000015
ODF4	rs2313148	17	8251845	3’ downstream	T>C	0.366	0.57 (0.44 – 0.74)	0.0000177
C9orf135	rs10511973	9	72466275	intron SNP	A>G	0.361	1.73 (1.35 – 2.21)	0.0000179
ITPR2	rs7302093	12	26602682	intron SNP	C>T	0.104	2.41 (1.53 – 3.79)	0.0000216
LOC100130088	rs12657212	5	154653619	5’ upstream	A>C	0.093	2.53 (1.70 – 3.76)	0.0000257
FOXK2	rs6502124	17	80545156	intron SNP	G>A	0.048	4.02 (1.91 – 8.47)	0.0000283
SH3BGRL2	rs9443691	6	80441475	3’ downstream	G>A	0.155	0.44 (0.30 – 0.67)	0.0000297
PRL	rs9379382	6	22289461	intron SNP	T>C	0.477	1.79 (1.36 – 2.36)	0.0000305
CAST	rs11745122	5	96060738	intron SNP	T>C	0.120	0.48 (0.33 – 0.70)	0.0000335
NFYAP1	rs1508938	13	64755699	5’ upstream	A>T	0.404	1.64 (1.29 – 2.09)	0.0000445

^aThe SNPs are listed in order of decreasing statistical significance as indicated by the uncorrected p values.

^bNCBI build 37.1 of the human genome.

^cuncorrected p values.

SNP = single nucleotide polymorphism; UTR = untranslated region; HR = hazard ratio; CI = confidence interval