Table 1.
RTKs genes for screen
| Gene symbol | Official Full Name | Inhibitor | Associated with cardiotoxicity (Ref) |
|---|---|---|---|
| ERBB4 | v-erb-a erythroblastic leukemia viral oncogene homolog 4 | NA | NA |
| MST1R | macrophage stimulating 1 receptor | NA | NA |
| RYK | receptor-like tyrosine kinase | NA | NA |
| KDR | kinase insert domain receptor | sorafenib/sunitinib | [8,32] |
| NTRK1 | neurotrophic tyrosine kinase, receptor, type 1 | NA | NA |
| STYK1 | serine/threonine/tyrosine kinase 1 | NA | NA |
| EPHA3 | EPH receptor A3 | NA | NA |
| FLT1 | fms-related tyrosine kinase 1 | sorafenib/sunitinib | [8,32] |
| FGFR1 | fibroblast growth factor receptor 1 | PD-173074 | NA |
| AXL | AXL receptor tyrosine kinase | NA | NA |
| NTRK2 | neurotrophic tyrosine kinase, receptor, type 2 | NA | NA |
| TEK | TEK tyrosine kinase, endothelial | NA | NA |
| EGFR | epidermal growth factor receptor | erlotinib/gefitinib/lapatinib | [1,8] |
| ROR2 | receptor tyrosine kinase-like orphan receptor 2 | NA | NA |
| FLT3 | fms-related tyrosine kinase 3 | sorafenib/sunitinib | [8,32] |
| ALK | anaplastic lymphoma receptor tyrosine kinase | crizotinib | NA |
| ERBB3 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) | AZD8931 | NA |
| ERBB2 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 | Lapatinib | [1,32] |
| INSRR | insulin receptor-related receptor | NA | NA |
| EPHA6 | EPH receptor A6 | NA | NA |
| EPHA5 | EPH receptor A5 | NA | NA |
| EPHA7 | EPH receptor A7 | NA | NA |
| FGFR3 | fibroblast growth factor receptor 3 | Linifanib/AZD4547 | NA |
| MUSK | muscle, skeletal, receptor tyrosine kinase | NA | NA |
| RET | ret proto-oncogene | Motesanib | [8,32] |
| IGF1R | insulin-like growth factor 1 receptor | NVP-ADW742 | NA |
| CSF1R | colony stimulating factor 1 receptor | Linifanib | [8] |
| MET | met proto-oncogene (hepatocyte growth factor receptor) | AMG-208 | NA |
| EPHA2 | EPH receptor A2 | NA | NA |
| PDGFRB | platelet-derived growth factor receptor, beta polypeptide | Dasatinib/nilotinib | [1,8,32] |
| INSR | insulin receptor | NA | NA |
| FGFR2 | fibroblast growth factor receptor 2 | AZD4547 | NA |
| PTK7 | PTK7 protein tyrosine kinase 7 | NA | NA |
| KIT | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | nilotinib/sorafenib | [1,8,32] |
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide | Dasatinib/sunitinib | [1,8,32] |
| TIE1 | tyrosine kinase with immunoglobulin-like and EGF-like domains 1 | NA | NA |
| DDR2 | discoidin domain receptor tyrosine kinase 2 | NA | NA |
| DDR1 | discoidin domain receptor tyrosine kinase 1 | NA | NA |
| LTK | leukocyte receptor tyrosine kinase | NA | NA |
| EPHB3 | EPH receptor B3 | NA | NA |
| FGFR4 | fibroblast growth factor receptor 4 | BGJ398 | NA |
| EPHA8 | EPH receptor A8 | NA | NA |
| NTRK3 | neurotrophic tyrosine kinase, receptor, type 3 | NA | NA |
| FLT4 | fms-related tyrosine kinase 4 | sunitinib | [8,32] |
| EPHB4 | EPH receptor B4 | NA | NA |
| LMTK2 | lemur tyrosine kinase 2 | NA | NA |
| EPHA1 | EPH receptor A1 | NA | NA |
| AATK | apoptosis-associated tyrosine kinase | NA | NA |
| MERTK | c-mer proto-oncogene tyrosine kinase | NA | NA |
| TYRO3 | TYRO3 protein tyrosine kinase | BMS 777607 | NA |
| ROS1 | c-ros oncogene 1, receptor tyrosine kinase | NA | NA |
| EPHA4 | EPH receptor A4 | NA | NA |
| EPHB6 | EPH receptor B6 | NA | NA |
Ref, reference; NA, not available.