Table 1.
Baseline Demographic, Clinical and Laboratory Characteristics
| Parameter | Placebo (n=28) | Epoetin Alfa (n=28) | P value |
|---|---|---|---|
| Age (years) | 79 (11) | 74 (9) | 0.052 |
| Gender (% Female) | 64% | 71% | 0.33 |
| Ethnicity (% Hispanic) | 67% | 54% | 0.27 |
| Race | 0.59 | ||
| White | 68% | 68% | |
| Black | 29% | 32% | |
| Asian | 4% | 0% | |
| Body Size | |||
| Height (cm) | 156 (9) | 158 (7) | 0.27 |
| Weight (kg) | 75 (15) | 83 (19) | 0.11 |
| BSA (m2) | 1.8 (0.2) | 1.9 (0.2) | 0.07 |
| BMI (kg/m2) | 31 (5) | 34 (7) | 0.10 |
| Co Morbid Conditions (%) | |||
| Hypertension | 100% | 100% | 1.0 |
| Diabetes | 50% | 82% | 0.01 |
| COPD | 11% | 18% | 0.45 |
| Coronary Artery Disease | 54% | 68% | 0.3 |
| Obesity | 54% | 68% | 0.3 |
| Chronic Kidney Disease | 50% | 68% | 0.2 |
| Hemodynamics | |||
| Systolic BP (mm Hg) | 140 (15) | 146 (17) | 0.14 |
| Diastolic BP (mm Hg) | 65 (11) | 67 (11) | 0.55 |
| Mean BP (mm Hg) | 90 (10) | 93 (10) | 0.37 |
| Pulse Pressure (mm Hg) | 75 (15) | 79 (19) | 0.41 |
| Heart Rate (bpm) | 74 (14) | 67 (13) | 0.35 |
| Medications | |||
| ACE inhibitors | 14 (50%) | 9 (32%) | 0.17 |
| ARBs | 6 (21%) | 11 (39%) | 0.15 |
| Beta Blockers | 22 (79%) | 17 (61%) | 0.15 |
| Calcium Channel Blocker | 13 (46%) | 15 (54%) | 0.6 |
| Aldosterone Antagonists | 4 (14%) | 5 (18%) | 0.7 |
| Loop Diuretics | 23 (82%) | 19 (68%) | 0.2 |
| Thiazide Diuretics | 4 (14%) | 8 (29%) | 0.19 |
| Laboratory Assessment | |||
| Hemoglobin (gm/dl) | 10.4 (1) | 10.6 (1.2) | 0.46 |
| Platelet count (x10(9)/L) | 232 (64) | 233 (68) | 0.8 |
| Albumin (gm/dl) | 3.7 (0.5) | 3.8 (0.4) | 0.5 |
| Potassium (mmol/L) | 4.5 (0.6) | 4.6 (0.5) | 0.3 |
| Creatinine (mg/dl) | 1.51 (0.8) | 1.58 (0.7) | 0.7 |
| Estimated GFR (ml/min/m2) | 48 (18) | 46 (19) | 0.6 |
| Blood urea nitrogen (mg/dl) | 37 (16) | 33 (17) | 0.2 |
| B-type natriuretic peptide (pg/ml) | 373 (336) | 488 (392) | 0.2 |
| Iron (ug/dl) | 60 (38) | 61 (49) | 0.7 |
| Ferritin (ng/L) | 85 (73) | 87 (79) | 0.9 |
| Transferrin Saturation (%) | 20 (13) | 20 (14) | 0.8 |
| Pain and Depression | |||
| Geriatric Depression Scale (0–30) | 7±5 | 10±7 | 0.16 |
| WOMAC Scale (0–96) | 23±16 | 26±16 | 0.57 |
WOMAC = Western Ontario and McMaster Universities Osteoarthritis Index