Table 11.
Comparison of SBHV-P1, -P2 and -P4 atlas composition and accuracy with recent automated hippocampal segmentation techniques based on multi-atlas registration and label fusion.
| Method | Segmentation protocol | Anatomical Definition | DSC | JI | Validation Sample | Template Library Composition |
||
|---|---|---|---|---|---|---|---|---|
| Posterior | Alveus/Fi mbria |
Medial | ||||||
| (Hammers et al., 2007) | (Niemann et al., 2000) | − | + | + | 0.76 0.83 |
TLE Unilateral Sclerotic TLE Contralateral Side |
Healthy Young Adults |
|
| (van der Lijn et al., 2008) | Based on modified protocol similar to (Jack 1994)but including the entire hippocampal tail | + | + | + | 0.852 (left side) 0.864 (right side) |
Healthy Elderly | 20 Healthy Elderly Subjects |
|
| (Barnes et al., 2008a) | (Watson et al., 1992) | − | + | + | 0.87 0.86 |
NC AD |
NC and AD | |
| (Wolz et al., 2009) | N/Aα | N/A | N/A | N/A | 0.860 | NC, MCI and AD | NC, MCI and AD | |
| (Lotjonen et al., 2010) | N/Aα | N/A | N/A | N/A | 0.885β | NC, MCI and AD | NC, MCI and AD | |
| (Collins and Pruessner 2010) | (Pruessner et al., 2000) | + | + | − | 0.887 | 0.796 | Healthy Young Adults |
Healthy Young Adults |
| (Leung et al., 2010) | (Watson et al., 1992) | − | + | + | 0.80 0.81 0.79 |
NC MCI AD |
NC and AD | |
| (Wang et al., 2011b) | (Hasboun et al., 1996) | − | + | − | 0.887 0.908 0.872 0.893 |
0.798 0.833 0.774 0.808 |
NC NC (error corrected) MCI MCI (error corrected) |
NC and MCI |
| (Kim et al., 2012) | (Watson et al., 1992) | − | + | + | 0.835 0.854 0.807 0.841 0.824 0.823 |
NC (left side) NC (right side) LTLE (left side) LTLE (right side) RTLE (right side) RTLE (left side) |
NC, LTLE and RTLE |
|
| SBHC-P1 | (Haller et al., 1997) | + | − | + | 0.88 0.89 0.90 |
NC MCI AD |
NC, AD, Mixed Dementia, AD+SVD and VaD |
|
| SBHC- P 2 | (Killiany et al., 1993) | − | − | − | 0.86 0.88 0.88 |
NC MCI AD |
NC, AD, Mixed Dementia, AD+SVD and VaD |
|
| SBHC- P4 | (Pruessner et al., 2000) | + | + | − | 0.89 0.90 0.91 |
NC MCI AD |
NC, AD, Mixed Dementia, AD+SVD and VaD |
|
α
The authors reported that manual labels were provided by ADNI consortium”,
β
Best result was achieved using atlas selection and an expectation maximization algorithm.
DSC= Dice Similarity Coefficient, JI = Jaccard Index = (M ∩ A)/(M ∪ A), Where M is the manually traced label set, A is the SBHV automatically derived label set and ∩ is the intersection operator, (R or L) TLE= Right/Left Temporal Lobe Epilepsy, + = more inclusive protocol, − = less inclusive protocol