Table 5.

Voxel similarity measured using the Dice Similarity Coefficient (DSC) and associated interquartile range (IQR) between manual and SBHV automatic bilateral hippocampal labels for the Sunnybrook automated pipeline leave-one-out optimization dataset (template n=30), and Sunnybrook LOOCV dataset (template n=70). Values reported are based on the automated labels that were generated by nonlinear registration to the target space and label fusion of the 15 best matching MRI templates. P1= (Haller et al., 1997), P2=(Killiany et al., 1993), P3=(Malykhin et al., 2007), P4=(Pruessner et al., 2000) and P5=(Pantel et al., 2000).

Atlas Protocol	Median DSC	IQR	ICC	95% CI
Sunnybrook Optimization Experiment
P1	0.87	0.05	0.93	(0.56 – 0.98)
P2	0.85	0.04	0.86	(0.42 – 0.96)
P3	0.89	0.03	0.94	(0.79 – 0.98)
P4	0.88	0.03	0.94	(0.60 – 0.98)
P5	0.89	0.03	0.93	(0.76 – 0.98)
Sunnybrook LOOCV Experiment
P1	0.86	0.04	0.92	(0.72 – 0.96)
P2	0.85	0.04	0.88	(0.40 – 0.96)
P3	0.88	0.02	0.94	(0.80 – 0.99)
P4	0.88	0.03	0.91	(0.54 – 0.97)
P5	0.88	0.02	0.93	(0.72 – 0.97)