Table 6.

Median voxel similarity measured using the Dice Similarity Coefficient (DSC) and interquartile range (IQR) between manual and optimized automated right hippocampal labels for the ADNI-1 cross-validation experiment (N=30). Manual and automated labels were generated for P1, P2 and P4 from a random sample of ADNI-1 normal controls (NC) (N=10), persons with mild cognitive impairment (MCI) and Alzheimer’s Disease (AD). P1= (Haller et al., 1997) P2= (Killiany et al., 1993) and P4= (Pruessner et al., 2000).

Dx Group	Atlas Protocol	DSC (Median)	IQR	ICC	95% CI
NC (n=10)	P1	0.88	0.02	0.88	(0.32–0.97)
	P2	0.86	0.02	0.87	(0..03–0.98)
	P4	0.89	0.02	0.86	(0.24–0.97)
MCI (n=10)	P1	0.89	0.04	0.81	(0.01–0.96)
	P2	0.88	0.02	0.72	(0.06–0.94)
	P4	0.90	0.03	0.89	(0.02–0.98)
AD (n=10)	P1	0.90	0.02	0.97	(0.66–0.99)
	P2	0.88	0.03	0.94	(0.06–0.99)
	P4	0.91	0.01	0.95	(0.50–0.99)
All Groups	P1	0.89	0.02	0.93	(0.49–0.98)
(n=30)	P2	0.87	0.03	0.89	(0.05–0.97)
	P4	0.90	0.02	0.93	(0.43–0.98)