Table 8.
Alzheimer’s Disease Neuroimaging Initiative-1 group-wise cross-validation experiment median and interquartile range (IQR) uncorrected right hippocampal volumes derived from manual (Man) and automated (Auto) labeling methods based on 3 anatomically unique segmentation protocols (P1= (Haller et al., 1997) P2=(Killiany et al., 1993) and P4= (Pruessner et al., 2000)) (n=30). Percent normalized volume differences (NVDs) are based on the difference between right hippocampal manual and automatic labels and are reported as percentages with a bootstrap 95% confidence intervals (CI) and interquartile ranges (IQR). Manual and automated labels were generated across protocols for a random sample of normal controls (NC), persons with mild cognitive impairment (MCI) and Alzheimer disease (AD).
| Dx Group | Atlas Protocol |
Method | Volume (mm3) | % Normalized Volume Difference | ||
|---|---|---|---|---|---|---|
| Median | IQR | Median | IQR | |||
| NC (n=10) | P1 | Auto | 2319..72 | 723.37 | 8.12 | 4.81 |
| Man | 2346.69 | 894.89 | ||||
| P2 | Auto | 1686.64 | 627.85 | 7.63 | 11.1 | |
| Man | 1813.89 | 557.87 | ||||
| P4 | Auto | 2533.29 | 789.69 | 9.28 | 6.51 | |
| Man | 2578.03 | 935.98 | ||||
| MCI (n=10) | P1 | Auto | 2100.76 | 438.24 | 8.50 | 4.78 |
| Man | 2297.82 | 457.91 | ||||
| P2 | Auto | 1663.79 | 382.55 | 9.01 | 12.55 | |
| Man | 1938.60 | 381.28 | ||||
| P4 | Auto | 2285.13 | 479.33 | 6.33 | 5.06 | |
| Man | 2457.76 | 452.20 | ||||
| AD (n=10) | P1 | Auto | 1559.38 | 542.48 | 4.27 | 4.84 |
| Man | 1697.74 | 696.87 | ||||
| P2 | Auto | 1188.74 | 520.27 | 9.91 | 7.74 | |
| Man | 1360.42 | 682.75 | ||||
| P4 | Auto | 1732.02 | 548.51 | 5.85 | 9.09 | |
| Man | 1890.68 | 792.54 | ||||
| All Groups (n=30) | P1 | Auto | 2026.19 | 820.31 | 7.95 | 5.59 |
| Man | 2198.50 | 636.57 | ||||
| P2 | Auto | 1532.41 | 572.95 | 8.73 | 8.29 | |
| Man | 1760.89 | 589.61 | ||||
| P4 | Auto | 2227.76 | 894.41 | 7.42 | 7.22 | |
| Man | 2392.86 | 686.24 | ||||