Table 9.

Protocol-specific standardized β coefficients grouped by diagnosis for ADNI-1 participants’ cognitive test performance versus hippocampal volumetry. The standardized β represents the number of standard deviations the cognitive measure increases/decreases with a one standard deviation increase of the hippocampal measurement. Note, significant standardized β values (p<0.05) are indicated in bold. Both the logical memory 1 (LM) immediate recall test and the Auditory Verbal Learning Test (AVLT) (sum of Trials I–IV) baseline and 24-month change in test scores were associated with corresponding absolute total (right + left) hippocampal volumes and 24-month percent hippocampal atrophy. All cross-sectional models included age, gender and intra-cranial volume whereas all longitudinal linear models controlled for age and gender. MCI = Mild Cognitive Impairment and AD = Alzheimer’s disease, P1= (Haller et al., 1997), P2= (Killiany et al., 1993), P3= (Malykhin et al., 2007), P4= (Pruessner et al., 2000) and P5= (Pantel et al., 2000).

	P1		P2		P3		P4		P5
	β	p-value	β	p-value	β	p-value	β	p-value	β	p-value
Baseline Hippocampal Volume & AVLT Score
MCI	0.22	<0.001	0.19	0.001	0.22	0.001	0.23	<0.001	0.22	<0.001
AD	0.22	0.021	0.21	0.025	0.22	0.017	0.27	0.003	0.22	0.016
Baseline Hippocampal Volume & LM Score
MCI	0.14	0.019	0.11	0.05	0.14	0.013	0.16	0.005	0.14	0.013
AD	0.24	0.005	0.22	0.011	0.25	0.004	0.28	0.001	0.26	0.003
24 month atrophy & AVLT change
MCI	−0.07	0.25	−0.03	0.629	−0.08	0.247	−0.09	0.153	−0.08	0.247
AD	−0.01	0.912	−0.02	0.832	−0.01	0.894	−0.01	0.914	−0.01	0.930
24 month atrophy & LM change
MCI	−0.17	0.008	−0.10	0.11	−0.18	0.005	−0.22	<0.001	−0.18	0.004
AD	−0.16	0.106	−0.15	0.134	−0.14	0.159	−0.126	0.205	−0.137	0.171