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Molecular action of glucocorticoids and dissociative steroids. Classic pharmacologic glucocorticoids have anti-inflammatory, membrane fluidity, and glucocorticoid response element (GRE)-mediated transcriptional activities. Dissociative steroids retain membrane and anti-inflammatory subactivities associated with efficacy, but do not retain the GRE-mediated transcriptional activities associated with side-effect profiles. GR, glucocorticoid receptor.
