TABLE 3.

Univariate and Multivariate Analyses of the Baseline and Time-Dependent Factors Associated With Survival Among 903 Persons First Prescribed Any Triple Combination ARV Therapy

Variable	Unadjusted HR (95% CI)	Adjusted HR (95% CI)
Gender
Female	1.00 (—)	1.00 (—)
Male	1.24 (0.74 to 2.07)	0.99 (0.55 to 1.79)
Age (yrs)	1.02 (1.00 to 1.04)	1.04 (1.02 to 1.06)
Baseline CD4 cell count    (per 100 cells/mm3 increment)	0.68 (0.57 to 0.81)	0.73 (0.58 to 0.93)
Baseline Plasma HIV-1   RNA level (log10 copies/mL)	2.58 (1.34 to 4.95)	2.14 (0.85 to 5.41)
Baseline AIDS diagnosis
No	1.00 (—)	1.00 (—)
Yes	1.94 (1.18 to 3.18)	1.48 (0.81 to 2.74)
IDU
No	1.00 (—)	1.00 (—)
Yes	1.35 (0.88 to 2.07)	1.34 (0.82 to 2.21)
Baseline regimen
NNRTI	1.00 (—)	1.00 (—)
PI boosted	1.38 (0.87 to 2.18)	0.91 (0.47 to 1.75)
Adherence level (time varying)
≥95%	1.00 (—)	1.00 (—)
<95%	2.79 (1.84 to 4.23)	3.13 (1.95 to 5.05)
Year of first therapy
2003–2004	1.00 (—)	1.00 (—)
2001–2002	1.08 (0.62 to 1.88)	1.91 (0.99 to 3.72)
2000	1.28 (0.69 to 2.39)	2.96 (1.46 to 6.00)

The univariate model used Cox proportional models. The multivariate model, using marginal structural models, considered as time-dependent confounders AIDS diagnosis, CD4 cell count, HAART therapy, and plasma HIV-1 RNA level. The exposure of main interest in this model was time-dependent adherence to therapy (<95% versus ≥95%).

ARV, antiretroviral.