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. 2013 Mar 4;110(12):4738–4743. doi: 10.1073/pnas.1222803110

Fig. 2.

Fig. 2.

Basal transmission and release probability are elevated in middle-aged Pten cKO mice. (A) Basal synaptic transmission, as assessed by the input/output relation of the fEPSP amplitude as a function of stimulation in nearby stratum moleculare, is normal at DGC synapses of young (8–12 wk) Pten cKO mice. (WT: n = 14 slices, seven mice; Pten cKO: n = 14 slices, seven mice; P > 0.05). (B) The input/output relation is enhanced in middle-aged (14–19 wk) Pten cKO mice (WT: n = 12 slices, six mice; Pten cKO: n = 12 slices, six mice. *P < 0.05, **P < 0.01). (C) The input/output relation is reduced in old (20–30 wk) WT mice to the same values as in old Pten cKO mice (WT: n = 11 slices, six mice: Pten cKO: n = 11 slices, six mice; P > 0.05). (D) PPR is unaltered at DGC synapses of young Pten cKO mice (WT: n = 5 slices, five mice: Pten cKO: n = 13 slices, five mice; P > 0.05. (E) PPR is decreased at DGC synapses of middle-aged Pten cKO mice (WT: n = 6 slices, four mice; Pten cKO: n = 7 slices, four mice. *P < 0.05, **P < 0.01). (F) PPR is unaltered at DGC synapses of old Pten cKO mice (WT: n = 5 slices, five mice; Pten cKO: n = 5 slices, five mice; P > 0.05).