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PERK/UPR inhibition reduces the tumor hypoxic fraction. (A) Pimonidazole (pimo) immunohistochemistry (pimonidazole positive viable fraction, green; blood vessels, red; Hoechst dye, blue) and (B) H&E on U373 isogenic tumors. (C) Quantification of pimonidazole immunohistochemistry of the viable tumor tissue and (D) necrotic fraction.
