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. 2013 Feb 4;110(12):4804–4809. doi: 10.1073/pnas.1216100110

Fig. 3.

Fig. 3.

Epigenetic regulation of mGlu2 receptors by LAC in FSL rats. (A) mGlu2 receptors expression in prefrontal cortex and hippocampus of FRL and FSL rats treated with saline or LAC for 3 or 21 d. n = 4 (3 d) or 6 (21 d). *P < 0.05 vs. all other values. F = 8.54 and 13.9 at 3 d, 12.9 and 12.4 at 21 d, for prefrontal cortex and hippocampus, respectively. (B) mRNA levels of mGlu2 and mGlu3 receptors in prefrontal cortex and hippocampus of FRL and FSL rats treated with saline or LAC. n = 6. P < 0.05 vs. the respective values of FRL rats (*) and vs. FSL rats treated with saline (#). F = 91.6. (C) Increased acetylation of p65/NF-κB in prefrontal cortex and hippocampus of FSL rats, n = 6. *P < 0.05 vs. the respective values of FSL rats treated with saline. (D) mGlu2 receptors expression in prefrontal cortex and hippocampus of FRL and FSL rats treated with sodium salicylate and/or LAC, n = 4. *P < 0.05 vs. the corresponding values obtained in FRL rats. F = 1.58E-002 and 9.22 for prefrontal cortex and hippocampus, respectively. (E) Levels of acetylated H3K27 bound to the Grm2 promoter gene in prefrontal cortex and hippocampus of FRL and FSL rats treated with saline or LAC. n = 6. *P < 0.05 vs. all other values. F = 8.7 and 8.3 for prefrontal cortex and hippocampus, respectively. (F) mGlu2 receptors expression in prefrontal cortex of FRL and FSL rats treated with saline or MS-275 for 21 d. n = 4. *P < 0.05 vs. all other values. F = 10.16.