Figure 3.
Sertraline exposure increased low frequency heart rate variability. Sertraline-exposed mice (white bars, N=12 mice from 7 litters) had significantly increased very low frequency (VLF) heart rate variability by carotid telemetry compared to control mice (black bars, N=6 mice from 5 litters) (a). Following chlorisondamine, VLF and low frequency (LF) spectral power were almost entirely eliminated (b). By electrocardiography (c), sertraline-exposed mice had increased VLF, LF, and high-frequency (HF) spectral power compared to control mice. After metoprolol, sertraline exposed mice had significantly decreased VLF spectral power (d) but all spectral power was reduced. * P<0.05 versus control.
