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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Pediatr Res. 2012 Dec 11;73(3):286–293. doi: 10.1038/pr.2012.183

Figure 5.

Figure 5

Sertraline exposed mice have increased expression of the serotonin transporter protein (5-HTT). PCR was performed on midbrain and cerebral cortex homogenates obtained from control and SSRI-exposed mice (gray bars). Expression of the serotonin transporter protein and serotonin receptor 5-HT2B were quantified and compared to control mice. Midbrain and cerebral cortex expression of 5-HTT mRNA is significantly increased in SSRI-exposed male mice compared to control mice (a). Midbrain 5-HTT expression is significantly increased compared to cortex (a). No differences were observed in expression of 5-HT2B receptors between brain regions or between sertraline exposed mice and control mice (b). N = 7–10 mice from 5–10 litters. *P<0.05 versus control. **P<0.05 versus cortex.