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Mean heart rates (HR) by telemetry following injections with sympathetic and parasympathetic antagonist.
| Medication (dose) | Measurement | Saline | Sertraline |
|---|---|---|---|
| 10 ml/kg/d | 5 mg/kg/d | ||
| N = 10 | N = 11 | ||
| Prazosin ( 1mg/kg) | HR, bpm | 534 ± 92 | 518 ± 14 |
| HR, % baseline | 99 ± 13 | 100 ± 13 | |
| Scopolamine (2mg/kg) | HR, bpm | 613 ±13 | 633 ± 20 |
| HR, % baseline | 120 ± 3* | 120 ± 4* | |
| Metoprolol ( mg/kg) | HR, bpm | 504 ± 9 | 486 ± 35 |
| HR, % baseline | 99 ± 3 | 91 ± 7 |
bpm = beats per minute.
p < 0.05.
