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. 2013 Jan 21;591(Pt 6):1489–1506. doi: 10.1113/jphysiol.2012.247684

Figure 6. Vasoactive intestinal polypeptide relaxes the WT and VIP−/− mouse IAS in a concentration-dependent manner and this is reduced by VIP6–28.

Figure 6

A–D, sample traces showing the response to VIP in the absence (A and C) and presence (B and D) of VIP6–28. E, summary graph of the concentration–response relationship for VIP in the absence and presence of VIP6–28 (30 μm). There is a small but significant (& p<0.05) difference in the VIP–relaxation relationship in the VIP−/− (n = 4) vs. the WT mouse (n = 5) in control conditions, whereas both relationships shift significantly (*p<0.05) to the right in the presence of VIP6–28. One-way ANOVA with Tukey's post hoc test. Shown are mean values ± SEM. Both MRS2500 (1 μm) and l-NNA (100 μm) were present throughout.