Figure 3. Changes in rat skeletal muscle PGC-1α and Tfam subcellular localization following exhaustive exercise.

A, following 3 h of recovery PGC-1α is increased in subsarcolemmal (SS) mitochondria. B, immediately post-exercise, Tfam is transiently increased in both the SS and the intermyofibrillar (IMF) mitochondria; n = 6 for all independent experiments. Data are expressed as mean ± SEM. *P < 0.05, significantly different from rest. Ten micrograms of mitochondrial protein was loaded for all conditions.