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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Pharmacol Res. 2013 Jan 31;70(1):126–138. doi: 10.1016/j.phrs.2013.01.008

Figure 2.

Figure 2

Changes in vascular ion channel expression during hypertension. Voltage-gated L-type Ca2+ channels (CaV1.2) are upregulated and voltage-gated K+ channels (KV) are downregulated in hypertension. The changes in expression may be the cause of vasoconstriction and increased blood pressure or a result of sustained elevation in blood pressure. Large-conductance Ca2+ -activated K+ channels (BK) are upregulated during hypertension, possibly as a compensatory mechanism inhibiting further increases in blood pressure.