Figure 1.

Overall Fold of BVDV1 E2

(A) Cartoon representation of the crystal structure of BVDV1 E2 obtained at pH8. A dimer of BVDV1 E2 is seen in the crystal. Domains of monomer A starting from the N terminus are colored in blue, green, yellow and red, respectively. The sugars are shown as magenta sticks and disulfide bridges are represented as cyan spheres.

(B) Linear representation of BVDV1 E2 showing the four domains DA, DB, DC and DD with their domain boundaries. Coloring as in a.

(C) Cartoon representation of the crystal structure of BVDV1 E2 obtained at pH5. Domains DA of monomers A and B are disordered (the transparent surface rendered shows the position of the domains when ordered at higher pH).

See also Figures S1, S2, S3, and S4.