Figure 3.

Interactions of BVDV1 E2 and Their Locations

(A) Location of histidine (H70) of domain DA, which is conserved among pestiviruses and that may trigger an order-disorder transition of this domain at low pH.

(B) The potential host cell receptor binding site in domain DB colored in pink. Domain DB is rotated as shown.

(C) The interface of monomers A (shown colored) and B (shown in gray) contains a strand swap and hydrophobic residues such as phenylalanines, tyrosines and tryptophanes drawn as sticks. Domains DD of molecules A and B are linked by a disulfide bridge (cyan sphere) to form a covalent homodimer.

See also Figure S1.