Figure S1.

Conservation of Aggregation-Prone and Nonaggregation-Prone Residues in Nine Different Fungi, Related to Figure 1

The program TANGO was used to determine aggregation prone residues in the nine strains. The aggregation profile of S. cerevisiae was taken as a reference. The alignments of the orthologous sequences for the nine yeast strains were obtained from Tuller and Ruppin (Tuller et al., 2009). The x-axis shows the fractions of residues that are present in all eight (category 8), only a fraction (categories 7 to 1) or none of the other fungal species (category 0). The y-axis shows the % of residues in aggregation prone (red bars) or non-aggregation-prone (grey bars) segments, respectively. The distributions of conservation of aggregation prone and non-aggregation prone residues are significantly different with aggregation prone residues more conserved than non-aggregation prone residues (p = 1x10⁻⁶; Wilcoxon test).