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. 2013 Mar 5;10(5):475–497. doi: 10.7150/ijms.5798

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Fig 5 — Dissociated epithelial cells within lymphoid follicles with increased vascular density. Two sets of two adjacent CRC tissue sections (A-D and E-H) from two node-positive cases were double Immunostained for CK AE1/3 (red) plus LCA or D2-40 (brown) or for CK-19 (red) plus CD34 or D2-40 (brown). Circles identify the low magnification views of the structures in B, D, F, and H. Thick and thin arrows identify dissociated epithelial cells and associated lymphocytes (B) or lymphatic ducts (D, F, and H), respectively. Note that the vascular density in each of the follicles is substantially increased and some disseminated cells are located within these follicles. A, C, E, and G: 100X. B, D, F, and H: a higher magnification (300X) of A, C, E, and G, respectively.