Fig 8.

Pre-invasive-invasive junction adjacent to large lymphocyte aggregates. A CRC tissue section was double immunostained for CK AE1/3 (red) and collagen IV (brown). The circle in A identifies the low magnification views of the structures in B and C, and the circle in B identifies a gap in the MM (arrowheads). Black and blue stars identify the invasive lesion and normal epithelial structures, respectively. Curve lines identify a tongue-like epithelial cell projection invading the submucosa through focally disrupted MM. Note that this cell projection appears to be directly budding from a normal epithelial structure. A: 80X. B: A higher (200X) of A.