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A 52-year-old man presenting with abdominal adenopathy and blastic bone lesions on CT with unknown primary. PET/CT demonstrated widespread malignancy including an FDG-avid lesion in the right medial orbit with associated soft tissue thickening as seen above (SUVmax 4.8). Biopsy of a chest wall node revealed poorly differentiated non-small cell carcinoma with neuroendocrine features suggestive of a gastrointestinal primary.
