Table 4.
Multivariate survival analysis
| hTERT mRNA Expression |
Telomerase Activity |
Telomere Length |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| HR* | 95% Confidence Interval (CI) | P | HR* | 95% CI† | P | HR* | 95% CI† | P | |
| Variable without interaction term | |||||||||
| Age, ≤60/>60 y | 1.15 | 0.69–1.91 | .60 | 0.87 | 0.53–1.45 | .60 | 0.89 | 0.53–1.49 | .66 |
| Sex | 0.73 | 0.44–1.24 | .24 | 0.74 | 0.44–1.24 | .25 | 0.72 | 0.42–1.21 | .21 |
| KPS ≥80/>80 | 2.07 | 1.13–3.79 | .018* | 2.08 | 1.13–3.82 | .019* | 2.11 | 1.14–3.90 | .017* |
| Treatment | 5.03 | 2.49–9.93 | .001* | 5.02 | 2.55–9.89 | .001* | 5.18 | 2.60–10.29 | .001* |
| IDH1 mutation status | 2.80 | 0.81–9.70 | .10 | 2.81 | 0.81–9.76 | .10 | 2.80 | 0.82–9.56 | .101 |
| hTERT mRNA expression | 1.02 | 0.61–1.71 | .93 | ||||||
| Telomerase activity | 1.03 | 0.62–1.70 | .91 | ||||||
| Telomere length | 0.93 | 0.57–1.52 | .80 | ||||||
| Variable with interaction term | |||||||||
| hTERT mRNA Expression × Age | .033* | ||||||||
| Telomerase Activity × Age | .024* | ||||||||
| Telomere Length × Age | .22 | ||||||||
*Adjusted hazard ratio (HR) for death.