Figure 2.

Wild-type and A30P mutant-type αS secondary structure transition stabilities. The stability of secondary structure transitions between two specific secondary structure components per residue for the wild-type (WT) and A30P mutant-type (A30P) αS proteins based on extensive Gibbs free energy calculations performed using our recently developed theoretical strategy. The color scale corresponds to the free energy value associated with the specific secondary structure transition between two secondary structure components for a specific residue.