Table 3.

Hazard Ratios for Cardiovascular Events in ISH Subjects With White-Coat Hypertension vs Normotensive Subjects According to Sex, Age, Pulse Pressure, and Diabetic Status

	Untreated					Treated
	Events/Subjects, n					Events/Subjects, n
Stratification	Normotensives	White-Coat HT	Adjusted Hazard Ratio (95% CI)	P		Normotensives	White-Coat HT	Adjusted Hazard Ratio (95% CI)	P
Women	98/3048	8/131	0.61 (0.29–1.27)	0.19	}P=0.04	41/287	16/104	0.82 (0.46–1.49)	0.52
Men	134/2223	39/203	1.44 (0.99–2.10)	0.06		32/144	20/58	1.33 (0.74–2.39)	0.34
<60 y	76/4300	4/108	1.66 (0.60–4.56)	0.33		13/192	2/35	0.66 (0.15–2.98)	0.60
≥60 y	156/971	43/226	1.09 (0.77–1.55)	0.61		60/239	34/127	1.09 (0.70–1.69)	0.70
Nondiabetics	219/5101	39/309	1.03 (0.72–1.47)	0.88	}P=0.05	65/383	32/136	1.12 (0.73–1.74)	0.60
Diabetics	13/170	8/25	2.68 (1.10–6.54)	0.03		8/48	4/26	0.56 (0.16–1.93)	0.36

ISH indicates isolated systolic hypertension; HT, hypertension.

The broad definition of cardiovascular events was used (see Methods section). The hazard ratios in the untreated subjects express the risk vs the untreated normotensive subgroup. The hazard ratios in the treated subjects express the risk vs the treated subjects with normalized blood pressure. All of the hazard ratios were stratified for cohort and adjusted for sex, age, body mass index, serum cholesterol, current smoking status, and diabetes mellitus.