Table 2. Hazard Ratios for Cardiovascular End Points in Relation to Clinic and Home Blood Pressure at Entry for the Whole Cohort and by Treatment Status.

		Fatal and Nonfatal Cardiovascular End Points Combined
Blood pressure index	Cardiovascular Death	All	Stroke	Cardiac
All subjects (n=6470)
End points, n	294	716	393	336
Systolic blood pressure
Clinic	1.11 (1.04–1.17)‡	1.09 (1.05–1.13)§	1.12 (1.06–1.17)§	1.05 (1.00–1.11)
Home	1.13 (1.05–1.21)†	1.19 (1.14–1.25)§	1.28 (1.20–1.37)§	1.10 (1.03–1.18)†
Diastolic blood pressure
Clinic	1.05 (1.00–1.11)	1.07 (1.04–1.11)§	1.09 (1.04–1.14)‡	1.04 (0.99–1.10)
Home	1.04 (0.97–1.11)	1.13 (1.08–1.17)§	1.19 (1.13–1.25)§	1.05 (0.99–1.12)
Treated (n=1452)
End points, n	136	302	168	142
Systolic blood pressure
Clinic	1.02 (0.93–1.11)	1.01 (0.96–1.07)	1.07 (0.99–1.16)	0.94 (0.86–1.02)
Home	1.16 (1.04–1.29)‡	1.15 (1.08–1.24)§	1.31 (1.18–1.45)§	1.03 (0.93–1.14)
Diastolic blood pressure
Clinic	1.00 (0.93–1.08)	1.03 (0.98–1.08)	1.04 (0.97–1.11)	1.00 (0.92–1.08)
Home	1.07 (0.97–1.19)	1.11 (1.04–1.17)†	1.19 (1.10–1.29)§	1.00 (0.91–1.11)
Untreated (n=5018)
End points, n	158	414	225	194
Systolic blood pressure
Clinic	1.19 (1.10–1.28)§	1.15 (1.09–1.20)§	1.15 (1.08–1.23)§	1.15 (1.07–1.23)‡
Home	1.10 (1.00–1.21)	1.21 (1.14–1.28)§	1.26 (1.16–1.37)§	1.16 (1.06–1.26)‡
Diastolic blood pressure
Clinic	1.10 (1.02–1.18)*	1.11 (1.06–1.16)§	1.13 (1.07–1.20)§	1.08 (1.00–1.15)*
Home	1.00 (0.91–1.09)	1.14 (1.08–1.20)§	1.18 (1.09–1.27)§	1.08 (1.00–1.18)

Hazard ratios (95% CIs) reflect the risk associated with 10- and 5-mm Hg increases in systolic and diastolic blood pressure, respectively. Hazard ratios were adjusted for cohort, sex, age, body mass index, smoking, history of cardiovascular disease, diabetes mellitus, treatment with antihypertensive drugs, and serum total cholesterol. The associations between clinic systolic blood pressure and cardiovascular end points were markedly steeper in the untreated as compared with the treated population (P<0.05 for all comparisons).

Significance of the hazard ratios:

^*P≤0.05;

^†P≤0.01;

^‡P≤0.001;

^§P≤0.0001.