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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: Trends Mol Med. 2012 Dec 5;19(2):74–82. doi: 10.1016/j.molmed.2012.10.011

Figure 2.

Figure 2

Rho GTPase signaling and NFκB activation. a. Oncogenic HA-tagged Dbl inducible mouse embryonic fibroblasts (MEFs) show a time dependent loss of IKBα activity, nuclear translocation of NFκB and initiation of NFκB-induced transcription. b. Proliferation of induced and uninduced HA-Dbl MEFs in low serum (1%) and the inhibition of growth in the presence of 0.5 μM of the NFκB inhibitor BAY 11-7082 or 5 μM of the glutaminase inhibitor 968.