Table 2. Standardized Hazard Ratios in Relation to 24-h Systolic Blood Pressure and Estimated Glomerular Filtration Rate in 5322 Participants.

		24-h Systolic Pressure		1/HR eGFR
End Point (No.)	Model	Hazard Ratio	P Value	Hazard Ratio	P Value
Mortality
All causes (513)	A	1.12 (1.03–1.22)	0.0081	1.05 (0.91–1.20)	0.50
	FA	1.12 (1.03–1.22)	0.0080	1.05 (0.91–1.21)	0.49
Cardiovascular (206)	A	1.33 (1.18–1.50)	<0.0001	1.34 (1.07–1.67)	0.012
	FA	1.33 (1.18–1.50)	<0.0001	1.35 (1.07–1.69)	0.010
Noncardiovascular (275)	A	0.96 (0.85–1.08)	0.46	0.89 (0.74–1.08)	0.23
	FA	0.95 (0.84–1.08)	0.46	0.89 (0.74–1.08)	0.23
Fatal plus nonfatal events
All cardiovascular (555)	A	1.37 (1.27–1.47)	<0.0001	1.15 (1.01–1.31)	0.035
	FA	1.37 (1.27–1.47)	<0.0001	1.15 (1.01–1.32)	0.033
Cardiac (335)	A	1.28 (1.16–1.41)	<0.0001	1.08 (0.91–1.27)	0.40
	FA	1.28 (1.16–1.41)	<0.0001	1.07 (0.91–1.27)	0.40
Coronary (257)	A	1.18 (1.05–1.32)	0.0056	1.07 (0.89–1.30)	0.46
	FA	1.18 (1.05–1.32)	0.0055	1.08 (0.89–1.30)	0.45
Stroke (218)	A	1.57 (1.40–1.76)	<0.0001	1.33 (1.08–1.64)	0.009
	FA	1.57 (1.40–1.76)	<0.0001	1.34 (1.08–1.66)	0.007

eGFR is the glomerular filtration rate estimated from the Chronic Kidney Disease Epidemiology Collaboration equation (CKD-EPI), as given in reference 22. Hazard ratios, presented with 95% CI, express the risk associated with a 1-SD increase in 24-h systolic blood pressure or a 1-SD decrease in eGFR. For eGFR, the inverse of the hazard ratio is presented, so that higher values, associated with lower eGFR, reflect higher risk. All models were adjusted for center, sex, age, body mass index, smoking and drinking, serum cholesterol, diabetes mellitus, history of cardiovascular disease, and antihypertensive treatment. Adjusted models (A) include either the 24-h systolic blood pressure or eGFR, whereas fully adjusted models (FA) include both 24-h systolic blood pressure and eGFR in addition to the aforementioned covariables. eGFR indicates estimated glomerular filtration rate.