. Author manuscript; available in PMC: 2013 Mar 25.

Published in final edited form as: Pediatr Res. 2012 Feb 15;71(4 0 2):500–510. doi: 10.1038/pr.2011.58

Table 3.

Summary of studies utilizing oncolytic viruses to target pediatric CSC by tumor type

Tumor Type	Virus Type, Name	Outcome	References
Glioma	HSV-1, M002	CD133+ CSC and CD133- tumor cells equally sensitive	21
MDB	SVV, wild-type	CD133+ CSC equally sensitive to CD133- cells	58
		Not all xenografts sensitive
NB	HSV-1, rQNestin34.5	Prevented CSC from forming tumors in athymic nude mice	15
	MYXV, wild-type	CSC appear sensitive in preliminary studies	78
	VSV, VSV	Possible resistance of CSC in preliminary studies	78
RMS	HSV-1, M002	CD133+ CSC and CD133- tumor cells equally sensitive	U

CSC, cancer stem cells; MDB, medulloblastoma; MYXV, myxoma virus; NB, neuroblastoma; RMS, rhabdomyosarcoma; U, unpublished