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Measurement of the uncoupling activity of 1 and 2 in C2C12 myoblasts. We measured the OCR of C2C12 myoblasts before and after injection of 1, 2, or DMSO (the solvent control). The addition of protonophore 1 increased the OCR of C2C12 myoblasts. The addition of 2 also resulted in a rise in OCR, consistent with a depletion of the pmf. The maximum OCR was achieved at 0.6 μM of 1 and 30 μM of 2. Error bars represent two standard deviations of the mean (n = 8).
