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. Author manuscript; available in PMC: 2014 Mar 15.
Published in final edited form as: Cancer Res. 2013 Jan 9;73(6):1892–1899. doi: 10.1158/0008-5472.CAN-12-2609

Figure 7.

Figure 7

HER2-specific NK-92 cells accumulate at the tumor and have preserved function. A, IHC for granzyme B highlights an NK-92 cell releasing granzyme B into the surrounding extra-cellular space (white arrows). An adjacent apoptotic tumor cell can be seen (black arrow). B, granzyme B-containing NK-92 cell (white arrow) causing apoptosis in a tumor cell (black arrow). At 24 hrs, a 1:100 ratio of effector:tumor cells is statistically no different (p > 0.05) in causing tumor cell lysis than higher starting ratios, C. This is the ratio of effector-to-tumor cells that was achieved in vivo in group 3.