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. 2012 Sep 4;21(23):5147–5158. doi: 10.1093/hmg/dds365

Figure 5.

Figure 5.

Mutant Twinkle reduces Parkin expression in SNC. (A) Parkin and TH immunostaining in SNC. Parkin expression was decreased in the SNC of transgenic mice. (B) The mean intensity of Parkin expression in SNC (WT = 3, TG = 3, P = 4.54–06, two-tailed). (C and D) Western blot analysis. Twinkle mutant resulted in the reduction of Parkin expression in PC12 cells after 48 h transfection, three independent experiments (P = 0.019, two-tailed), CTL: only transfection reagents, no plasmid, WT: transfection with Twinkle WT plasmids. MUT: transfection with Twinkle duplicate plasmids. *P≤ 0.05.