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. 2012 Sep 4;21(23):5147–5158. doi: 10.1093/hmg/dds365

Figure 7.

Figure 7.

Mutant Twinkle reduces proteasome activity. (A) PC12 cells were transfected with Twinkle duplicate plasmids and Twinkle WT plasmids, respectively, for 48 h. Proteasome activities were significantly reduced in PC12 cells transfected with Twinkle duplicate, four independent experiments, P < 0.001. (B). Duplicate Twinkle plasmids were co-transfected with Parkin plasmids or empty vector into PC12 cells. WT Twinkle plasmids were co-transfected with empty vector into PC12 cells as controls. Proteasome activities were decreased in PC12 cells with Twinkle duplicate and empty vector compared with Twinkle WT and empty vector (P < 0.05). However, proteasome activities are increased in PC12 cells with Twinkle duplicate and Parkin plasmids compared with Twinkle duplicate and empty vector plasmids (P < 0.05). (C) Proteasome activities in midbrain of 1- and 23-month mice (1 month: WT = 3, TG = 3, P = 0.39, one-tailed; 23month: WT = 4, TG = 4, P = 0.29, one-tailed). *P≤ 0.05.