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. Author manuscript; available in PMC: 2013 Mar 25.
Published in final edited form as: Neurosurgery. 2012 Apr;70(4):1003–1010. doi: 10.1227/NEU.0b013e31823e5332

FIGURE 2.

FIGURE 2

RCAS wild-type p53-induced phosphatase 1 (WIP1) suppresses p53 expression after exposure to cisplatin in A375-TVA cells. Western blot of WIP1, p53 and actin (control) in A375-TVA cells. Cells unexposed to cisplatin demonstrate minimal WIP1 and p53 expression at 24 and 48 hours. Expression of WIP1 and p53 increases after exposure to cisplatin at 24 and 48 hours. A375-TVA cells infected with RCAS-green fluorescent protein (GFP) demonstrate a similar increase in both WIP1 and p53 expression after exposure to cisplatin at both 24 and 48 hours. A375-TVA cells infected with RCAS-WIP1 demonstrate decreased p53 expression at both 24 and 48 hours after exposure to cisplatin, verifying the suppressive effect of WIP1 on p53.