TABLE.
Vector | Tumor Incidence |
---|---|
RCAS-SHH | 3/40 (8%) |
RCAS-SHH + RCAS-WIP1 | 12/35 (34%) |
RCAS-WIP1 | 0/30 (0%) |
The difference in tumor formation between mice injected with RCAS-SHH and RCAS-SHH + RCAS-WIP1 is significant (χ2 test, P = .0038). SHH, sonic hedgehog; WIP1, wild-type p53-induced phosphatase 1.