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Incidence of Tumor Formation in Ntv-a Mice Injected With RCAS-SHH, RCAS-SHH + RCAS-WIP1, and RCAS-WIP1a
| Vector | Tumor Incidence |
|---|---|
| RCAS-SHH | 3/40 (8%) |
| RCAS-SHH + RCAS-WIP1 | 12/35 (34%) |
| RCAS-WIP1 | 0/30 (0%) |
The difference in tumor formation between mice injected with RCAS-SHH and RCAS-SHH + RCAS-WIP1 is significant (χ2 test, P = .0038). SHH, sonic hedgehog; WIP1, wild-type p53-induced phosphatase 1.
