Figure 1. Local radiation therapy enhances the therapeutic efficacy of T cell therapy.

B6 mice were inoculated s.c. in the flank with 1.5 × 10⁶ D5 cells on day 0. Mice were treated with either local radiation therapy (RT) on day 7 to 11, adoptively transferred TDLN cells on day 11 (AT), or local radiation combined with T cell therapy (RT+AT). A: Tumor size in mice was measured every other day and data are reported as the average tumor area (mm²) ± SEM of 6 or more mice per group. B: Mice survival was recorded as the percentage of surviving animals over time after tumor inoculation. One of 3 representative experiments is shown. C: The median survival time (MST) of each experimental group from 3 independent experiments was calculated and reported as mean ± SEM of 8 or more mice per group. D: The percent increase in MST was calculated as (MSTexperimental – MSTcontrol)/MSTcontrol x 100% for each treatment group relative to untreated control mice. * p < 0.05, ** p < 0.01, for RT+AT versus all other groups.