Table 1.

Nanocarrier	Size (nm)	Zeta potential (mv)	Antibodies per nanocarrier		Nanocarriers bound per cella
Single Targeting:
Anti-ICAM	219±4.54	−9.37±0.47	273±37.0		49.9±9.80
Anti-TfR-8D3	265±27.9	−14.5±3.4	185±2.37		31.6±2.28
Anti-TfR-R17	235±15.1	−15.9±1.63	220±6.27		3.71±0.61
Combined Targeting:
Anti-TfR-R17/8D3	258±12.2	−14.5±3.67	8D3: 115±0.94	R17: 140±7.22	11.9±0.76
Anti-TfR-R17/IgG	251±13.2	−9.50±0.28	R17: 154±0.87	IgG: 136±0.31	6.72±1.63
Anti-TfR-8D3/IgG	255±40.0	−12.9±3.89	8D3: 98.5±4.02	IgG: 152±9.74	14.7±1.16
Anti-ICAM/anti-TfR (clone R17)	216±11.1	−11.6±0.14	Anti-ICAM: 132±12.4	Anti-TfR: 145±9.72	21.0±4.12
Anti-ICAM/IgG	240±17.9	−9.02±0.34	Anti-ICAM: 124±24.5	IgG 139±2.41	16.6±2.50

Data are Mean ± S.E.M.; Ab = antibody; N/A = not applicable;

^ap<0.05 compared to control IgG NCs, in all cases (by Student’s t-test).