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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Orthod Waves. 2013 Feb 23;72(1):1–10. doi: 10.1016/j.odw.2013.01.040

Figure 1. The tooth and bone gene cluster on human chromosome 4.

Figure 1

ENAM (enamelin) AMBN (ameloblastin), AMTN (amelotin), and ODAM (odontogenic, ameloblast-associated), which are enamel matrix genes, are located on 4q13 (about 770 kb) and SPARCL1, DSPP (dentin sialophosphoprotein), DMP1 (dentin matrix acidic phosphoprotein 1), BSP (bone sialoprotein/IBSP, integrin-binding sialoprotein), MEPE (matrix extracellular phosphoglycoprotein), and OPN (osteopontin/SPP1, secreted phosphoprotein 1), which are dentin and bone matrix genes are on 4q22 (about 375 kb). AMEL is located sex chromosomes. The X chromosome gene, AMELX, is shown. Each arrow illustrates a gene and the transcriptional direction.