Table 3. Top 20 canonical pathways within the first 24 h of immune response after the first vaccination.

Ingenuity Canonical Pathway	Pathway Category	−log p at 2 h	−log p at 4 h	−log p at 8 h	−log p at 24 h
Fcγ Receptor-mediated Phagocytosis inMacrophages and Monocytes	1	6.79	2.25	2.37	6
CD28 Signaling in T Helper Cells	1	4.92	n.s.	1.68	5.63
CTLA4 Signaling in Cytotoxic T Lymphocytes	1	3.64	n.s.	n.s.	6.06
T Cell Receptor Signaling	1	2.2	n.s.	3.22	5.79
Regulation of IL-2 Expression in Activated andAnergic T Lymphocytes	1; 2	1.48	n.s.	4.13	2.31
Clathrin-mediated Endocytosis Signaling	1; 3; 9	4.15	2.66	n.s.	4.63
ILK Signaling	4	4.69	2.03	n.s.	1.59
FAK Signaling	4	3.83	1.58	1.68	4
VEGF Signaling	4; 10	3.11	2.98	2.6	4.74
IGF-1 Signaling	4; 10	1.61	3.5	2.63	3.54
Integrin Signaling	4; 5; 7	6.2	2.74	2.94	4.08
Protein Ubiquitination Pathway	5	1.45	3.7	5.69	n.s.
ERK/MAPK Signaling	5	3.01	2.05	4.26	5.09
Glucocorticoid Receptor Signaling	5	2.59	2.95	4.76	3.65
Estrogen Receptor Signaling	6	n.s.	3.82	4.02	n.s.
Aldosterone Signaling in Epithelial Cells	6; 12	2.6	2.47	3.06	2.12
NRF2-mediated Oxidative Stress Response	8; 13	2.11	2.14	5.93	1.66
Actin Cytoskeleton Signaling	9	5.15	3.11	4.62	4.81
Regulation of Actin-based Motility by Rho	11	3.94	3.68	1.36	1.62
Ephrin Receptor Signaling	9	2.71	n.s.	n.s.	5.45

1 Cellular Immune Response.

2 Cytokine Signaling.

3 Pathogen-Influenced Signaling.

4 Cellular Growth, Proliferation and Development.

5 Intracellular and Second Messenger Signaling.

6 Nuclear Receptor Signaling.

7 Cell Cycle Regulation.

8 Cellular Stress and Injury.

9 Organismal Growth and Development.

10 Growth Factor Signaling.

11 Neurotransmitters and Other Nervous System Signaling.

12 Cardiovascular Signaling.

13 Ingenuity Toxicity List Pathways.

n.s. not significant.