Figure 3. Calcineurin activity, BOS and overall survival.

BOS-free survival was estimated at 5 years after transplantation by the Kaplan and Meier method. (A) Calcineurin activity (CN-a) monitoring during the first 24 months after transplantation: although not statistically significant, the survival without BOS was higher in patients who displayed CN-a levels within the range of 12–102 pmol/mg/min as compared to patients who exhibited at least one CN-a value outside this range of 12–102 pmol/mg/min during the first 24 months following transplantation (76% vs 43%, p = 0.4717, Log-rank test). (B) CN-a monitoring from the 6^th month to the 24^th month after transplantation: the survival without BOS was significantly higher in patients who displayed CN-a levels within the range of 12–102 pmol/mg/min as compared to that of patients who exhibited at least one CN-a value outside this range from the 6^th month to the 24^th months following transplantation (80% vs 40%, p = 0.0118, Log-rank test). (C) CN-a monitoring from the 6^th to the 24^th month after transplantation: the threshold values were further separated in 2 groups : <12 pmol/mg/min, >102 pmol/mg/min. The BOS-free survival in patients from each of these groups was compared to that from patients who displayed CN-a levels within the range of 12–102 pmol/mg/min. A significant reduction of the survival without BOS was found in patients who displayed CN-a levels higher than 102 pmol/mg/min (40% vs 80%, p = 0.037, Log-rank test), whereas a reduction in BOS-free survival in the limit of statistical significance was found in patients who displayed CN-a levels lower than 12 pmol/mg/min (49% vs 80%, p = 0.0574, Log-rank test). (D) Calcineurin activity and overall survival: no significant difference was found in the overall survival between the 2 groups of patients exhibiting calcineurin activity levels within or outside of the range of 12–102 pmol/mg/min.